Dermatosis perineal y glútea en un paciente paliativo con rápida respuesta a tratamiento oral / Perineal and gluteal dermatosis in a palliative patient with rapid response to oral treatment

Los pacientes con enfermedades terminales presentan frecuentes y diversos problemas de la piel debido a sus enfermedades de base y complicaciones de su situación: encamamiento, inmovilidad, malnutrición, incontinencia, etc. Estas lesiones ocasionan importante sufrimiento por el dolor, prurito, incomodidad, alteración de la imagen corporal y falta de intimidad. Por lo tanto, su abordaje eficaz por los médicos de cuidados paliativos es prioritario. En algún caso es posible conseguir un tratamiento causal efectivo en el corto periodo de tiempo disponible como demuestra el paciente descrito

Patients with terminal disease frecuently present various skin problems due to their underlying disease and complications of their clinical situation: bed-ridden, immobility, malnutrition, incontinence, etc. These lesions commonly produce significant suffering because of pain, itching, discomfort, body image distortion and lack of intimacy. Thus, an effective management of these by palliative care is prioritary. Occasionally, a specific treatment efficacious in the short time avalilable is possible as the present case shows

Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2.

Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged periods of time. Two major genotypes, subtype 1 and subtype 2, are recognized, although currently only a single complete genomic sequence corresponding to MCV subtype 1 is available. Using next-generation sequencing techniques, we report the complete genomic sequence of four new MCV isolates, including the first one derived from a subtype 2. Comparisons suggest a relatively distant evolutionary split between both MCV subtypes. Further, our data illustrate concurrent circulation of distinct viruses within a population and reveal the existence of recombination events among them. These results help identify a set of MCV genes with potentially relevant roles in molluscum contagiosum epidemiology and pathogenesis.

Nódulo umbilical / Umbilical nodule

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Dos casos de necrólisis epidérmica tóxica localizadaasociada a radioterapia / Two cases of localized toxic epidermal necrolysis associated with radiotherapy

La aparición de necrólisis epidérmica tóxica por radioterapia es poco frecuente, aumentando su incidencia al asociar anticonvulsionantes. Describimos los casos de 2 mujeres de 33 y 29 años, con metástasis cerebrales de melanoma y carcinoma de mama, respectivamente, en tratamiento con dexametasona, fenitoína y sesiones de radioterapia que desarrollaron una erupción maculopapular en cabeza y mitad superior del tronco, asociada a mucositis. Las lesiones cutáneas evolucionaron a grandes ampollas flácidas en las localizaciones mencionadas. Destacamos el papel etiopatogénico de la asociación de fenitoína y radioterapia, así como la localización del proceso en la mitad superior del cuerpo (AU)

Nevoid hypertrichosis and hypomelanosis.

A girl with multiple lesions of nevoid hypertrichosis and linear hypopigmentation following Blaschko's lines is presented. She had no extracutaneous anomalies. We hypothesize that this unusual coexistence of skin lesions may represent a further example of "twin spotting".